Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 10/20 | 0.50 |
| ▸ | ACE | P12821 | 5/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.50 |
| ▸ | CPA1 | P15085 | 3/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869455 | 1.00 | MME (0.50) | MMEACEACE2CPA1CTSL | |
| SCHEMBL5869476 | 1.00 | MME (0.50) | MMEACEACE2CPA1CTSL | |
| SCHEMBL5869466 | 1.00 | MME (0.50) | MMEACEACE2CPA1CTSL | |
| SCHEMBL5869134 | 0.87 | FOLH1 (0.49) | MMEACEACE2CPA1CTSL | |
| SCHEMBL5869128 | 0.87 | FOLH1 (0.49) | MMEACEACE2CPA1CTSL | |
| SCHEMBL5869139 | 0.87 | FOLH1 (0.49) | MMEACEACE2CPA1CTSL | |
| SCHEMBL8248574 | 0.85 | MME (0.65) | MMEACEACE2CPA1FOLH1 | |
| SCHEMBL5870071 | 0.83 | ACE2 (0.53) | MMEACEACE2CPA1CTSL | |
| SCHEMBL5870067 | 0.83 | ACE2 (0.53) | MMEACEACE2CPA1CTSL | |
| SCHEMBL5870063 | 0.83 | ACE2 (0.53) | MMEACEACE2CPA1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |