Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.52 |
| ▸ | DRD3 | P35462 | 7/20 | 0.52 |
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | HTR3A | P46098 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596447 | 0.92 | DRD3 (0.54) | HTR1ADRD3DRD2HTR3AHTR2A | |
| SCHEMBL7603379 | 0.92 | HTR1A (0.52) | HTR1ADRD3DRD2HTR3AHTR2A | |
| SCHEMBL7600758 | 0.89 | DRD3 (0.52) | HTR1ADRD3DRD2HTR3AHTR2A | |
| SCHEMBL7598706 | 0.89 | HTR1A (0.52) | HTR1ADRD3DRD2HTR2AHTR2C | |
| SCHEMBL7599611 | 0.88 | DRD3 (0.49) | HTR1ADRD3DRD2HTR3AHTR2A | |
| SCHEMBL7601406 | 0.88 | HTR1A (0.49) | HTR1ADRD3DRD2HTR3AHTR2A | |
| SCHEMBL7601003 | 0.88 | HTR1A (0.51) | HTR1ADRD3DRD2HTR3AHTR2A | |
| SCHEMBL7603029 | 0.88 | HTR1A (0.49) | HTR1ADRD3DRD2HTR3AHTR2A | |
| SCHEMBL7598449 | 0.87 | DRD3 (0.50) | HTR1ADRD3DRD2HTR2AHTR2C | |
| SCHEMBL7600222 | 0.87 | HTR1A (0.48) | HTR1ADRD3DRD2HTR3AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |