Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7024476 | 1.00 | LCK (0.71) | LCKNPC1RAB9AJAK2JAK3 | |
| SCHEMBL7014887 | 0.93 | LCK (0.69) | LCKNPC1RAB9AJAK2JAK3 | |
| SCHEMBL7593900 | 0.92 | LCK (0.73) | LCKNPC1RAB9AJAK2JAK3 | |
| SCHEMBL7022474 | 0.92 | LCK (0.73) | LCKNPC1RAB9AJAK2JAK3 | |
| SCHEMBL7023569 | 0.91 | LCK (0.62) | LCKJAK2JAK3MAPK14MKNK1 | |
| SCHEMBL7023427 | 0.91 | LCK (0.62) | LCKNPC1RAB9AJAK2JAK3 | |
| SCHEMBL7676552 | 0.91 | LCK (0.62) | LCKNPC1RAB9AJAK2JAK3 | |
| SCHEMBL7586853 | 0.90 | LCK (0.67) | LCKJAK2JAK3MAPK14MKNK1 | |
| SCHEMBL7021876 | 0.90 | LCK (0.67) | LCKJAK2JAK3MAPK14MKNK1 | |
| SCHEMBL7101240 | 0.90 | LCK (0.60) | LCKNPC1RAB9AJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |