Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7023427 | 1.00 | LCK (0.62) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7014887 | 0.92 | LCK (0.69) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7024476 | 0.91 | LCK (0.71) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7600966 | 0.91 | LCK (0.71) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7023569 | 0.90 | LCK (0.62) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7101235 | 0.89 | LCK (0.60) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7101240 | 0.89 | LCK (0.60) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7021278 | 0.89 | LCK (0.60) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7022787 | 0.88 | LCK (0.70) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7027375 | 0.88 | LCK (0.63) | LCKJAK2JAK3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |