Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | ADH1B | P00325 | 2/20 | 0.43 |
| ▸ | ADH1A | P07327 | 2/20 | 0.43 |
| ▸ | ADH7 | P40394 | 2/20 | 0.43 |
| ▸ | ADH1C | P00326 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7596439 | 1.00 | TSHR (0.65) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL11508516 | 0.97 | TSHR (0.69) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL7512916 | 0.97 | TSHR (0.69) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL11508173 | 0.97 | TSHR (0.69) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL1248078 | 0.97 | TSHR (0.69) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL4211605 | 0.97 | TSHR (0.69) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| SCHEMBL1781797 | 0.97 | TSHR (0.69) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| Bromide SCHEMBL28930278 | 0.94 | TSHR (0.77) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| Bromide SCHEMBL7694600 | 0.94 | TSHR (0.77) | TSHRALDH1A1PAOXCYP2C19CYP1A2 | |
| Bromide SCHEMBL29463772 | 0.94 | TSHR (0.77) | TSHRALDH1A1PAOXCYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0917465-B1 | ANTIMALARIAL AND ANTI-BABESIOSIS AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AGENTS | VIRBAC SA (FR) | 2002-11-20 | — | — | EP | claimed |