Sugi Predict

Sugi Predict / Compounds / Acarbose

Acarbose

Acarbose

SCHEMBL7601414

CCCC(=O)[O-].C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)O[C@@H]3CO)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O.[Na+]

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AMY2AMGAM

The experimentally established mechanism targets of Acarbose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ AMY2A known ✓ P04746 9/20 0.81
▸ MGAM known ✓ O43451 6/20 0.81
▸ SI P14410 5/20 0.81
▸ GAA P10253 4/20 0.81
▸ AMY1A P0DUB6 3/20 0.81
▸ CNR1 P21554 1/20 0.81
▸ PTGS1 P23219 1/20 0.81
▸ PDE4A P27815 1/20 0.81
▸ PDE3A Q14432 1/20 0.81
▸ MGAM2 Q2M2H8 1/20 0.81
▸ ALDH1A1 P00352 1/20 0.81
▸ GLA P06280 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acarbose SCHEMBL19736300 0.90 AMY2A (1.00) AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL681337 0.90 AMY2A (1.00) AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL9929862 0.90 AMY2A (1.00) AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL22252576 0.90 AMY2A (1.00) AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL22252575 0.90 AMY2A (1.00) AMY2AMGAMSIGAAAMY1A
SCHEMBL14409049 0.90 AMY2A (1.00) AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL4068725 0.90 AMY2A (1.00) AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL14223718 0.90 AMY2A (1.00) AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL22651301 0.90 AMY2A (1.00) AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL611277 0.90 AMY2A (1.00) AMY2AMGAMSIGAAAMY1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1257263-A2 MICROCOMPETITON AND HUMAN DISEASE SCI Pharmaceuticals, Inc. (US) 2002-11-20 — — EP disclosed
WO-2001060408-A2 MICROCOMPETITON AND HUMAN DISEASE SCI PHARMACEUTICALS, INC. (US) 2001-08-23 — — WO disclosed