Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.37 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27512112 | 0.96 | GSTP1 (0.36) | GSTP1HDAC4HDAC2HDAC8SLC6A2 | |
| Hydrochloric Acid SCHEMBL7979475 | 0.96 | GSTP1 (0.35) | GSTP1HDAC4HDAC2HDAC8SLC6A2 | |
| Hydrochloric Acid SCHEMBL27494608 | 0.83 | GSTP1 (0.36) | GSTP1HDAC4HDAC2HDAC8SLC6A2 | |
| Hydrochloric Acid SCHEMBL27495381 | 0.82 | PDCD1 (0.33) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29612316 | 0.82 | GSTP1 (0.38) | GSTP1HDAC4HDAC2HDAC8SLC6A2 | |
| Hydrochloric Acid SCHEMBL5952828 | 0.82 | GSTP1 (0.38) | GSTP1HDAC4HDAC2HDAC8SLC6A2 | |
| Hydrochloric Acid SCHEMBL5709184 | 0.82 | PDCD1 (0.35) | ALDH1A1HPGDHSD17B10CYP2A6 | |
| Hydrochloric Acid SCHEMBL29424591 | 0.82 | PDCD1 (0.35) | ALDH1A1HPGDHSD17B10CYP2A6 | |
| Hydrochloric Acid SCHEMBL3163965 | 0.82 | PDCD1 (0.35) | ALDH1A1HPGDHSD17B10CYP2A6 | |
| SCHEMBL7940308 | 0.82 | GSTP1 (0.44) | GSTP1HDAC4HDAC2HDAC8SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1946748-B | Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV | 2011-04-06 | — | — | CN | claimed |
| CN-1946748-A | Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV (NL) | 2007-04-11 | — | — | CN | claimed |
| CN-101384624-B | Catalyst composition for olefin polymerization | NOVOLEN TECH HOLDINGS CV | 2012-07-04 | — | — | CN | disclosed |
| CN-1946748-B | Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV | 2011-04-06 | — | — | CN | disclosed |
| CN-1813009-B | Polyethylene wax, lost wax composition for precision casting containing the same, and method for producing mold for precision casting | MITSUI CHEMICALS INC | 2010-06-02 | — | — | CN | disclosed |
| CN-101538383-A | Lost-wax composition for precision casting and method for making pattern for precision casting | MITSUI CHEMICALS INC (JP) | 2009-09-23 | — | — | CN | disclosed |
| CN-101384624-A | Catalyst composition for olefin polymerization | NOVOLEN TECH HOLDINGS CV (NL) | 2009-03-11 | — | — | CN | disclosed |
| CN-101291977-A | Process for producing thermoplastic resin composition | MITSUI CHEMICALS INC (JP) | 2008-10-22 | — | — | CN | disclosed |
| CN-101291983-A | Process for producing thermoplastic resin composition | MITSUI CHEMICALS INC (JP) | 2008-10-22 | — | — | CN | disclosed |
| CN-100415858-C | Additive for lubricating oil and lubricating oil composition | MITSUI CHEMICALS INC (JP) | 2008-09-03 | — | — | CN | disclosed |
| CN-1946748-A | Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV (NL) | 2007-04-11 | — | — | CN | disclosed |
| CN-1281871-A | Flexible resin composition and its use | MITSUI CHEMICALS INC (JP) | 2001-01-31 | — | — | CN | disclosed |
| WO-2000022011-A2 | SUPPORTED POLYMERIZATION CATALYSTS | BOREALIS TECHNOLOGY OY (FI) | 2000-04-20 | — | — | WO | disclosed |
| CN-1246871-A | Propylene polymers incorporating polyethylene macromers | EXXON CHEMICAL PATENTS INC (US) | 2000-03-08 | — | — | CN | disclosed |
| CN-1217685-A | VULCANIZED MOLDING HAVING SURFACE DECORATIVE LAYER, PAINTED THERMOPLASTIC RESIN COMPOSITION AND PAINTED ELASTOMER COMPOSITION | MITSUI CHEMICALS INC (JP) | 1999-05-26 | — | — | CN | disclosed |
| CN-1216055-A | RUBBER COMPOSITIONS FOR TIRES | MITSUI CHEMICALS INC (JP) | 1999-05-05 | — | — | CN | disclosed |
| CN-1216053-A | SHRINKABLE FILM MADE FROM OLEFINE COPOLYMER | MITSUI CHEMICALS INC (JP) | 1999-05-05 | — | — | CN | disclosed |
| CN-1209827-A | 'alpha'-olefin/aromatic vinyl copolymer composition and products thereof | MITSUI CHEMICALS INC (JP) | 1999-03-03 | — | — | CN | disclosed |
| US-5840644-A | OLEFIN POLYMERIZATION CATALYSTS | TARGOR GMBH (DE) | 1998-11-24 | — | — | US | disclosed |
| US-5770753-A | ADDITION POLYMERIZATION CATALYST | TARGOR GMBH (DE) | 1998-06-23 | — | — | US | disclosed |