Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CAD | P27708 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28870475 | 0.85 | TYR (0.42) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL17011234 | 0.85 | TYR (0.42) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL5812119 | 0.85 | ALDH1A1 (0.42) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL5812114 | 0.85 | ALDH1A1 (0.42) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL23052374 | 0.83 | BIRC2 (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL19323020 | 0.83 | CYP2C9 (0.41) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL25144944 | 0.83 | MAPT (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL14519903 | 0.83 | BIRC2 (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL15786178 | 0.83 | HTT (0.52) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL19323524 | 0.83 | CYP2C9 (0.41) | MGAMGAASIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |