Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.51 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6839226 | 1.00 | ADORA2A (0.54) | ADORA2AADORA2BADORA3ADORA1TMIGD3 | |
| SCHEMBL7597688 | 0.88 | ADORA3 (0.47) | ADORA2AADORA2BADORA3ADORA1TMIGD3 | |
| SCHEMBL7103815 | 0.88 | ADORA3 (0.48) | ADORA2AADORA2BADORA3ADORA1TMIGD3 | |
| SCHEMBL6841471 | 0.88 | ADORA3 (0.51) | ADORA2AADORA2BADORA3ADORA1TMIGD3 | |
| SCHEMBL6841470 | 0.88 | ADORA3 (0.47) | ADORA2AADORA2BADORA3ADORA1TMIGD3 | |
| SCHEMBL8092182 | 0.85 | ADORA3 (0.44) | ADORA2AADORA2BADORA3ADORA1TMIGD3 | |
| SCHEMBL6839871 | 0.85 | PI4KA (0.55) | ADORA2AADORA2BADORA3ADORA1TMIGD3 | |
| SCHEMBL6839866 | 0.85 | PI4KA (0.55) | ADORA2AADORA2BADORA3ADORA1TMIGD3 | |
| SCHEMBL7762135 | 0.84 | ADORA3 (0.46) | ADORA2AADORA2BADORA3ADORA1TMIGD3 | |
| SCHEMBL6835048 | 0.83 | ADORA3 (0.56) | ADORA2AADORA2BADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051425-B1 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-10-30 | — | — | EP | disclosed |