Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.72 |
| ▸ | ESRRG | P62508 | 10/20 | 0.69 |
| ▸ | ESRRB | O95718 | 5/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | PGR | P06401 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | PLD2 | O14939 | 1/20 | 0.69 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.69 |
| ▸ | ESRRA | P11474 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7602724 | 1.00 | ESR1 (0.72) | ESR1ESRRGESRRBESR2MAPT | |
| SCHEMBL7597053 | 0.94 | ESR1 (0.68) | ESR1ESRRGESRRBESR2MAPT | |
| SCHEMBL7602293 | 0.83 | ESR1 (0.65) | ESR1ESRRGESR2MAPTMEN1 | |
| SCHEMBL15668666 | 0.81 | ESR1 (1.00) | ESR1ESRRGESRRBESR2MAPT | |
| Afimoxifene SCHEMBL640496 | 0.81 | ESR1 (1.00) | ESR1ESRRGESRRBESR2MAPT | |
| Afimoxifene SCHEMBL9189 | 0.81 | ESR1 (1.00) | ESR1ESRRGESRRBESR2MAPT | |
| SCHEMBL2165503 | 0.81 | ESR1 (1.00) | ESR1ESRRGESRRBESR2MAPT | |
| Afimoxifene SCHEMBL2132301 | 0.81 | ESR1 (1.00) | ESR1ESRRGESRRBESR2MAPT | |
| Tamoxifen SCHEMBL11899365 | 0.81 | ESR1 (0.97) | ESR1ESRRGESRRBESR2MAPT | |
| SCHEMBL7600265 | 0.80 | ESR1 (0.61) | ESR1ESRRGESR2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020161007-A1 | Non-steroidal modulators of estrogen receptors | PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2002-10-31 | — | — | US | claimed |
| US-20020161007-A1 | Non-steroidal modulators of estrogen receptors | PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2002-10-31 | — | — | US | disclosed |
| WO-2002066415-A2 | NON-STEROIDAL MODULATORS OF ESTROGEN RECEPTORS | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161007-A1 | Non-steroidal modulators of estrogen receptors | ESRRB, ESR2, ESRRG | ESR1 6/4885ESRRG 3/4885ESRRB 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.