⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996669 | 0.84 | DAO (0.44) | — | |
| SCHEMBL9144815 | 0.82 | F2 (0.70) | — | |
| SCHEMBL15525171 | 0.80 | — | — | |
| SCHEMBL77196 | 0.80 | — | — | |
| SCHEMBL3745752 | 0.80 | — | — | |
| SCHEMBL92875 | 0.80 | — | — | |
| SCHEMBL17088064 | 0.80 | — | — | |
| SCHEMBL1770739 | 0.80 | — | — | |
| SCHEMBL15525166 | 0.78 | — | — | |
| SCHEMBL16898895 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 963 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118530233-A | Preparation method of rivaroxaban and intermediate thereof | 武汉工程大学 | 2024-08-23 | — | — | CN | claimed |
| CN-114163395-B | Chiral oxazolinone derivative, synthesis method and application thereof in preparation of linezolid and rivaroxaban | 中国人民解放军空军军医大学 | 2023-10-10 | — | — | CN | claimed |
| CN-115947725-A | Preparation method of rivaroxaban | 南通常佑药业科技有限公司 | 2023-04-11 | — | — | CN | claimed |
| CN-115490678-A | Preparation method of high-purity rivaroxaban | 浙江苏泊尔制药有限公司 | 2022-12-20 | — | — | CN | claimed |
| CN-114685480-A | Method for refining and crushing rivaroxaban bulk drug | 江苏嘉逸医药有限公司 | 2022-07-01 | — | — | CN | claimed |
| EP-3565552-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF RIVAROXABAN INVOLVING NOVEL INTERMEDIATE | UNICHEM LAB LTD (IN) | 2022-05-11 | — | — | EP | claimed |
| CN-112159402-B | Preparation method of rivaroxaban | 南京法恩化学有限公司 | 2022-04-05 | — | — | CN | claimed |
| CN-114163395-A | Chiral oxazolinone derivatives, synthesis method and application thereof in preparation of linezolid and rivaroxaban | 中国人民解放军空军军医大学 | 2022-03-11 | — | — | CN | claimed |
| CN-109422720-B | Preparation method of low-cost and high-purity 5-chlorothiophene-2-formyl chloride | 新发药业有限公司 | 2021-07-20 | — | — | CN | claimed |
| US-11034683-B2 | Process for the preparation of rivaroxaban involving novel intermediate | UNICHEM LABORATORIES LTD (IN) | 2021-06-15 | — | — | US | claimed |
| CN-1906191-B | Preparation method | BAYER HEALTHCARE AG | 2010-05-26 | — | — | CN | claimed |
| US-7598378-B2 | Method for the production of 4-(4-aminophenyl)-3-morpholinone | BAYER SCHERING PHARMA AG (DE) | 2009-10-06 | — | — | US | claimed |
| US-7351823-B2 | Preparation process | BAYER HEALTHCARE AG (DE) | 2008-04-01 | — | — | US | claimed |
| JP-2007517816-A | — | — | 2007-07-05 | — | — | JP | claimed |
| US-20070066611-A1 | Method for the production of 4-(4-aminophenyl)-3-morpholinone | BAYER HEALTHCARE AG (DE) | 2007-03-22 | — | — | US | claimed |
| CN-1906191-A | Preparation method | BAYER HEALTHCARE AG (DE) | 2007-01-31 | — | — | CN | claimed |
| US-7157456-B2 | Anticoagulates for treating cardiovascular disorders, such as myocardial infarct, angina pectoris, restenoses after angioplasty, bypass, stroke; treatment of atherosclerosis, arthritis, Alzheimer's disease or cancer | BAYER HEALTHCARE AG (DE) | 2007-01-02 | — | — | US | claimed |
| EP-1720866-A1 | PRODUCTION METHOD | Bayer HealthCare AG (DE) | 2006-11-15 | — | — | EP | claimed |
| US-20050182055-A1 | 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide formed by reacting 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one hydrochloride with 5-chlorothiophene-2-carbonyl chloride | BAYER HEALTHCARE AG (DE) | 2005-08-18 | — | — | US | claimed |
| WO-2005068456-A1 | PRODUCTION METHOD | BAYER HEALTHCARE AG (DE) | 2005-07-28 | — | — | WO | claimed |