Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MDM4 | O15151 | 1/20 | 0.64 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | IL1RN | P18510 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15101547 | 1.00 | TSHR (0.64) | TSHRMDM4MDM2NPSR1KMT2A | |
| SCHEMBL27935101 | 0.89 | TSHR (0.51) | TSHRMDM4MDM2NPSR1KMT2A | |
| SCHEMBL2522737 | 0.87 | NPSR1 (0.61) | TSHRMDM4MDM2NPSR1KMT2A | |
| SCHEMBL315117 | 0.87 | NPSR1 (0.61) | TSHRMDM4MDM2NPSR1KMT2A | |
| SCHEMBL2519897 | 0.87 | NPSR1 (0.61) | TSHRMDM4MDM2NPSR1KMT2A | |
| SCHEMBL3050135 | 0.87 | NPSR1 (0.61) | TSHRMDM4MDM2NPSR1KMT2A | |
| SCHEMBL5686655 | 0.86 | NPSR1 (0.57) | TSHRMDM4MDM2NPSR1KMT2A | |
| SCHEMBL13536306 | 0.86 | MDM4 (0.62) | TSHRMDM4MDM2NPSR1KMT2A | |
| SCHEMBL12150049 | 0.85 | TSHR (0.49) | TSHRMDM4MDM2NPSR1KMT2A | |
| SCHEMBL25446628 | 0.84 | MDM4 (0.64) | TSHRMDM4MDM2NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102159545-A | Small molecule leptin receptor modulators | ASTRAZENECA AB | 2011-08-17 | — | — | CN | disclosed |
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |