Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 11/20 | 0.58 |
| ▸ | CCR3 | P51677 | 11/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 2/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7518021 | 0.88 | HRH1 (0.57) | HRH1CCR3FPR2PROKR1KDM4E | |
| SCHEMBL6397276 | 0.87 | HRH1 (0.56) | HRH1CCR3FPR2PROKR1KDM4E | |
| SCHEMBL6395820 | 0.85 | HRH1 (0.54) | HRH1CCR3FPR2PROKR1KDM4E | |
| SCHEMBL6398872 | 0.85 | HRH1 (0.59) | HRH1CCR3FPR2PROKR1KDM4E | |
| SCHEMBL6402580 | 0.83 | HRH1 (0.48) | HRH1CCR3FPR2PROKR1KDM4E | |
| SCHEMBL7598716 | 0.82 | HRH1 (0.49) | HRH1CCR3FPR2PROKR1KDM4E | |
| SCHEMBL6397887 | 0.81 | HRH1 (0.46) | HRH1CCR3FPR2PROKR1KDM4E | |
| SCHEMBL6398700 | 0.81 | HRH1 (0.49) | HRH1CCR3FPR2PROKR1KDM4E | |
| SCHEMBL6395690 | 0.81 | HRH1 (0.59) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL6396033 | 0.81 | HRH1 (0.59) | HRH1CCR3FPR2PROKR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002540204-A | — | — | 2002-11-26 | — | — | JP | claimed |
| EP-1165545-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-01-02 | — | — | EP | claimed |
| WO-2000058305-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-10-05 | — | — | WO | claimed |