Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.37 |
| ▸ | MTTP | P55157 | 3/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | MTR | Q99707 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 6/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771932 | 0.88 | MTTP (0.49) | DRD3MTTPADRA2AADRA1AKCNH2 | |
| SCHEMBL7599609 | 0.86 | MTTP (0.36) | DRD3MTTPADRA2AADRA1AKCNH2 | |
| SCHEMBL7600730 | 0.85 | HCRTR1 (0.40) | DRD3MTTPADRA2AADRA1AKCNH2 | |
| SCHEMBL7719459 | 0.84 | MTTP (0.41) | DRD3MTTPADRA2AADRA1AKCNH2 | |
| SCHEMBL7597136 | 0.83 | NPC1 (0.40) | DRD3MTTPADRA2AADRA1AKCNH2 | |
| SCHEMBL7598586 | 0.82 | DRD3 (0.39) | DRD3MTTPADRA2AADRA1AKCNH2 | |
| SCHEMBL7601003 | 0.80 | HTR1A (0.51) | DRD3HTR1AHTR2AHRH3DRD2 | |
| SCHEMBL7608953 | 0.80 | DRD3 (0.38) | DRD3HTR1AHTR2ADRD2 | |
| SCHEMBL7719553 | 0.79 | SMN1; SMN2 (0.46) | DRD3MTTPADRA2AADRA1AKCNH2 | |
| SCHEMBL7723307 | 0.79 | HTR1A (0.44) | DRD3MTTPADRA2AADRA1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |