Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HBB | P68871 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7607095 | 0.95 | HTR2A (0.42) | HTR2ACA1CA2TNKS2PBRM1 | |
| Hydrochloric Acid SCHEMBL5366067 | 0.83 | HTR2A (0.40) | HTR2ACA1CA2TNKS2PBRM1 | |
| Hydrochloric Acid SCHEMBL5363315 | 0.81 | HTR2A (0.42) | HTR2ACA1CA2TNKS2PBRM1 | |
| Hydrochloric Acid SCHEMBL5352775 | 0.81 | HTR2A (0.42) | HTR2ACA1CA2TNKS2PBRM1 | |
| SCHEMBL8857191 | 0.79 | HTR2A (0.42) | HTR2ACA1CA2TNKS2PBRM1 | |
| Hydrochloric Acid SCHEMBL9170197 | 0.77 | HTR2A (0.32) | HTR2A | |
| Hydrochloric Acid SCHEMBL5352133 | 0.77 | HTR2A (0.42) | HTR2ACA1CA2TNKS2PBRM1 | |
| Hydrochloric Acid SCHEMBL5358965 | 0.77 | HTR2A (0.42) | HTR2ACA1CA2TNKS2PBRM1 | |
| SCHEMBL7606771 | 0.75 | HTR2A (0.44) | HTR2ACA1CA2TNKS2PBRM1 | |
| SCHEMBL27379567 | 0.74 | HTR2A (0.38) | HTR2ACA1CA2TNKS2PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524624-B1 | Use of organometallic flurorenyl compounds. | PHILLIPS PETROLEUM CO (US) | 2002-05-15 | — | — | EP | claimed |
| EP-0524624-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1993-01-27 | — | — | EP | claimed |
| EP-0524624-B1 | Use of organometallic flurorenyl compounds. | PHILLIPS PETROLEUM CO (US) | 2002-05-15 | — | — | EP | disclosed |