Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 16/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | TSHR | P16473 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9189176 | 0.79 | ALDH1A1 (1.00) | ALDH1A1KMT2ATSHRSMN1; SMN2MEN1 | |
| SCHEMBL1805007 | 0.76 | SMN1; SMN2 (0.59) | ALDH1A1KMT2ATSHRSMN1; SMN2MEN1 | |
| SCHEMBL22519689 | 0.75 | ALDH1A1 (0.76) | ALDH1A1KMT2ATSHRSMN1; SMN2MEN1 | |
| SCHEMBL11317326 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KMT2ATSHRSMN1; SMN2MEN1 | |
| SCHEMBL2372138 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KMT2ATSHRSMN1; SMN2MEN1 | |
| SCHEMBL4038612 | 0.74 | ALDH1A1 (1.00) | ALDH1A1KMT2ATSHRSMN1; SMN2MEN1 | |
| SCHEMBL28330129 | 0.74 | TSHR (0.63) | ALDH1A1KMT2ATSHRSMN1; SMN2MEN1 | |
| SCHEMBL7600578 | 0.73 | ALDH1A1 (0.64) | ALDH1A1KMT2ATSHRSMN1; SMN2MEN1 | |
| SCHEMBL17912762 | 0.72 | ALDH1A1 (0.63) | ALDH1A1KMT2ATSHRSMN1; SMN2MEN1 | |
| SCHEMBL11887695 | 0.71 | ALDH1A1 (1.00) | ALDH1A1KMT2ATSHRSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |