Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.77 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | C1S | P09871 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5866196 | 0.88 | F2 (0.83) | F2PRSS2F10CACNA1B | |
| Hydrochloric Acid SCHEMBL5866080 | 0.87 | F2 (0.81) | F2PRSS2F10CACNA1B | |
| SCHEMBL5866240 | 0.81 | TMPRSS6 (0.57) | F2PRSS1PLGPRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL5866104 | 0.81 | TMPRSS6 (0.58) | F2PRSS1PLGPRSS2PRSS3 | |
| SCHEMBL5866155 | 0.79 | F2 (0.52) | F2PRSS1PLGPRSS2C1S | |
| SCHEMBL5866105 | 0.79 | KEAP1 (0.52) | F2ITGB3ITGA2BF10 | |
| Hydrochloric Acid SCHEMBL5866183 | 0.79 | KEAP1 (0.52) | F2ITGB3ITGA2BF10 | |
| SCHEMBL5866283 | 0.76 | SIRT2 (0.50) | F2PRSS1PLGPRSS2C1S | |
| Hydrochloric Acid SCHEMBL5866202 | 0.75 | SIRT2 (0.49) | F2PRSS1PLGPRSS2C1S | |
| SCHEMBL5866387 | 0.75 | MCL1 (0.56) | F2PRSS1PRSS2PRSS3ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0917528-B1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-18 | — | — | EP | claimed |