Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605723 | 0.95 | KMT2A (0.45) | KMT2ASMN1; SMN2PGRPDE4BPDE3A | |
| SCHEMBL13660706 | 0.95 | KMT2A (0.45) | KMT2ASMN1; SMN2PGRPDE4BPDE3A | |
| SCHEMBL7601792 | 0.88 | KMT2A (0.51) | KMT2ASMN1; SMN2PGRPDE4BPDE3A | |
| SCHEMBL7603999 | 0.88 | KMT2A (0.51) | KMT2ASMN1; SMN2PGRPDE4BPDE3A | |
| SCHEMBL1177677 | 0.81 | HPGD (0.35) | POLBALDH1A1 | |
| SCHEMBL1177679 | 0.81 | HPGD (0.35) | POLBALDH1A1 | |
| SCHEMBL1178010 | 0.81 | HPGD (0.35) | POLBALDH1A1 | |
| SCHEMBL7604005 | 0.81 | KMT2A (0.49) | KMT2ASMN1; SMN2PGRPDE4BPDE3A | |
| SCHEMBL7605782 | 0.80 | KMT2A (0.54) | KMT2ASMN1; SMN2PGRMEN1TP53 | |
| SCHEMBL7604162 | 0.80 | KMT2A (0.54) | KMT2ASMN1; SMN2PGRMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268625-B1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2012-05-16 | — | — | EP | disclosed |