Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 8/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.63 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.56 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.56 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27581742 | 0.93 | PDE7A (0.75) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL27581789 | 0.89 | PDE7A (0.74) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL7605580 | 0.89 | PDE7A (0.58) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL7606527 | 0.89 | PDE7A (0.70) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL27581790 | 0.89 | PDE7A (0.58) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL23407733 | 0.87 | PDE7A (0.68) | PDE7APDE4BPDE4DPDE7BIDO1 | |
| SCHEMBL1149232 | 0.87 | PDE7A (0.78) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL7641381 | 0.87 | PDE7A (0.55) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL6925412 | 0.87 | PDE7A (0.52) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL7610002 | 0.85 | PDE7A (0.59) | PDE7APDE4BPDE4DPDE7BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |