Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 15/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.41 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7781132 | 0.90 | FOLH1 (0.46) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL1374873 | 0.86 | FOLH1 (0.46) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL9323454 | 0.77 | FFAR3 (0.48) | HDAC1HDAC2TDP1 | |
| SCHEMBL2230782 | 0.77 | CHRM1 (0.76) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL1377042 | 0.77 | FOLH1 (0.43) | FOLH1GRM3NAALAD2 | |
| Hydrochloric Acid SCHEMBL27682490 | 0.75 | CHRM1 (0.73) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| Hydrochloric Acid SCHEMBL10460144 | 0.75 | CHRM1 (0.73) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| Bromide SCHEMBL7659007 | 0.75 | CHRM1 (0.73) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| Water SCHEMBL27701491 | 0.75 | CHRM1 (0.73) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL1373605 | 0.75 | FOLH1 (0.48) | FOLH1GRM3NAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514185-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-0949922-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-10-20 | — | — | EP | claimed |
| WO-1998013044-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |
| WO-2023202654-A1 | COMPOUND AND USE THEREOF | 同宜医药（苏州）有限公司 | 2023-10-26 | — | — | WO | disclosed |