Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 14/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605857 | 0.90 | FOLH1 (0.47) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL1377042 | 0.87 | FOLH1 (0.43) | FOLH1CA2MAPK1GRM3 | |
| SCHEMBL3446776 | 0.79 | CA2 (0.65) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL4401256 | 0.79 | AKR1B1 (0.56) | HDAC1HDAC2TDP1 | |
| SCHEMBL9323099 | 0.79 | AKR1B1 (0.50) | HDAC1HDAC2TDP1 | |
| SCHEMBL27656177 | 0.77 | CA2 (0.63) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL8653950 | 0.77 | FOLH1 (0.66) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL1374873 | 0.77 | FOLH1 (0.46) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL337293 | 0.75 | FOLH1 (0.67) | FOLH1TDP1 | |
| SCHEMBL1506904 | 0.75 | FOLH1 (0.67) | FOLH1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2001521512-A | — | — | 2001-11-06 | — | — | JP | claimed |
| EP-1019369-A1 | THIO DERIVATIVES AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2000-07-19 | — | — | EP | claimed |
| WO-1998045257-A1 | THIO DERIVATIVES AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-10-15 | — | — | WO | claimed |