Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 5/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606652 | 0.94 | BCHE (0.48) | BCHEKMT2AMAPTTP53ALDH1A1 | |
| SCHEMBL7616836 | 0.94 | MAPT (0.50) | BCHERAB9ASMN1; SMN2HPGDKMT2A | |
| SCHEMBL7605978 | 0.88 | BCHE (0.58) | BCHERAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL7605980 | 0.88 | BCHE (0.58) | BCHERAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL7612365 | 0.86 | MAPT (0.54) | BCHERAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL7609068 | 0.85 | BCHE (0.62) | BCHERAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL7622379 | 0.84 | MAPT (0.43) | BCHEHPGDKMT2AMAPTTP53 | |
| SCHEMBL7608561 | 0.84 | MAPT (0.44) | BCHESMN1; SMN2HPGDKMT2AMAPT | |
| SCHEMBL7614275 | 0.83 | SMN1; SMN2 (0.52) | BCHERAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL7610127 | 0.83 | IMPDH2 (0.51) | BCHERAB9ASMN1; SMN2HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100495-A4 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORP (US) | 2002-09-25 | — | — | EP | claimed |
| JP-2002521441-A | — | — | 2002-07-16 | — | — | JP | claimed |
| EP-1100495-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-23 | — | — | EP | claimed |
| WO-2000006153-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | claimed |
| EP-1100495-A4 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORP (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-1100495-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006153-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |