Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606176 | 0.87 | HDAC6 (0.44) | LMNATSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7606062 | 0.86 | HDAC6 (0.45) | LMNATSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7608926 | 0.86 | LMNA (0.43) | LMNATSHRCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL7612615 | 0.81 | MAPT (0.41) | LMNACRHBPCRHR2NPSR1CYP2D6 | |
| SCHEMBL7611332 | 0.78 | HDAC6 (0.44) | TSHRSMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL7613735 | 0.78 | HDAC6 (0.44) | — | |
| SCHEMBL7608458 | 0.78 | HDAC1 (0.40) | TSHRSMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL7613468 | 0.77 | HDAC6 (0.42) | LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7551884 | 0.76 | HDAC6 (0.44) | SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL7555714 | 0.75 | HDAC6 (0.45) | LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436965-B1 | INHIBITION OF PHOSPHODIESTERASE; 3-CARBOCYCLIC(ALKYL)OXY-2-ARYL(ALKYL)AMINOCARBONYL-1-ARYL(ALKYL)INDOLE OR AZAINDOLE DERIVATIVES | MERCK FROSST CANADA & CO. (CA) | 2002-08-20 | — | — | US | claimed |
| US-20020068756-A1 | PDE IV inhibiting amides, compositions and methods of treatment | MERCK FROSST CANADA LTD. (CA) | 2002-06-06 | — | — | US | claimed |
| US-6436965-B1 | INHIBITION OF PHOSPHODIESTERASE; 3-CARBOCYCLIC(ALKYL)OXY-2-ARYL(ALKYL)AMINOCARBONYL-1-ARYL(ALKYL)INDOLE OR AZAINDOLE DERIVATIVES | MERCK FROSST CANADA & CO. (CA) | 2002-08-20 | — | — | US | disclosed |
| US-20020068756-A1 | PDE IV inhibiting amides, compositions and methods of treatment | MERCK FROSST CANADA LTD. (CA) | 2002-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068756-A1 | PDE IV inhibiting amides, compositions and methods of treatment | PDE3A, PDE3B, PDE4A | PTGIR 51/4885LMNA 2374/4885TSHR 3295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.