Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PDE5A | O76074 | 3/20 | 0.43 |
| ▸ | SOD1 | P00441 | 2/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605721 | 0.83 | ALDH1A1 (0.50) | ALDH1A1GSK3AGSK3BSMN1; SMN2PDE5A | |
| SCHEMBL7611350 | 0.82 | ALDH1A1 (0.49) | ALDH1A1GSK3AGSK3BSMN1; SMN2PDE5A | |
| SCHEMBL7606509 | 0.82 | PDE5A (0.66) | PDE5ATBXAS1PTGS1PTGS2PDE3B | |
| SCHEMBL7607040 | 0.81 | ALDH1A1 (0.48) | ALDH1A1GSK3AGSK3BSMN1; SMN2PDE5A | |
| SCHEMBL5595499 | 0.78 | PDE5A (0.65) | ALDH1A1GSK3AGSK3BPDE5ATBXAS1 | |
| Hydrochloric Acid SCHEMBL7280328 | 0.77 | PDE5A (0.63) | ALDH1A1GSK3AGSK3BPDE5ATBXAS1 | |
| SCHEMBL7610465 | 0.76 | GBA1 (0.53) | ALDH1A1PDE5ATBXAS1PTGS1PTGS2 | |
| SCHEMBL7606590 | 0.75 | KDM4E (0.62) | ALDH1A1SMN1; SMN2PDE5ATBXAS1PTGS1 | |
| SCHEMBL7611433 | 0.75 | MAPK1 (0.53) | ALDH1A1PDE5ALMNAHPGDMAPK1 | |
| SCHEMBL7607878 | 0.74 | PDE5A (0.42) | ALDH1A1SMN1; SMN2PDE5ATBXAS1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020025968-A1 | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives | OSI PHARMACEUTICALS, INC. | 2002-02-28 | — | — | US | disclosed |
| US-5439895-A | Cardiovascular disorders; inhibitor of thromboxane A2 synthetase and cyclic guanosine 3',5'-monophosphate | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020025968-A1 | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives | VHL, MCL1, NFATC1 | ALDH1A1 1566/4885GSK3A 2671/4885GSK3B 2355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.