Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MLYCD | O95822 | 2/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.41 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123942 | 0.85 | HPGD (0.48) | KMT2AMLYCDLMNAALDH1A1HPGD | |
| SCHEMBL5710878 | 0.82 | HPGD (0.56) | KDM4EKMT2AMLYCDNAPRTUSP2 | |
| SCHEMBL11873778 | 0.80 | NAPRT (0.45) | KDM4EKMT2AMLYCDNAPRTCYP1A2 | |
| SCHEMBL8422261 | 0.80 | NAMPT (0.58) | KDM4EKMT2AMLYCDNAPRTCYP1A2 | |
| SCHEMBL16794763 | 0.79 | ALDH1A1 (0.58) | LMNAALDH1A1HPGDHDAC1GAA | |
| SCHEMBL27854800 | 0.78 | KDM4E (0.47) | KDM4EKMT2AMLYCDNAPRTCYP1A2 | |
| SCHEMBL12853918 | 0.78 | HTT (0.63) | KDM4EKMT2ANPSR1USP2LMNA | |
| SCHEMBL16875731 | 0.78 | ALDH1A1 (0.52) | ALDH1A1HPGDCA1CA9TP53 | |
| SCHEMBL10725189 | 0.77 | KDM4E (0.58) | KDM4EKMT2AMLYCDNAPRTCYP1A2 | |
| SCHEMBL27662505 | 0.76 | NAPRT (0.54) | KDM4EKMT2AMLYCDNAPRTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514185-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-0949922-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-10-20 | — | — | EP | claimed |
| WO-1998013044-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |