Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 4/20 | 0.74 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.74 |
| ▸ | ITGAL | P20701 | 4/20 | 0.74 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610324 | 0.87 | ITGB2 (0.96) | ITGB2ICAM1ITGALPDE7AKDM4E | |
| Hydrochloric Acid SCHEMBL7637698 | 0.85 | ITGB2 (1.00) | ITGB2ICAM1ITGALPDE7AKDM4E | |
| SCHEMBL7605654 | 0.83 | ITGB2 (0.59) | ITGB2ICAM1ITGALPDE7AKDM4E | |
| SCHEMBL7187676 | 0.79 | ITGB2 (0.80) | ITGB2ICAM1ITGALPDE7AKDM4E | |
| SCHEMBL3165346 | 0.79 | ITGB2 (0.72) | ITGB2ICAM1ITGALPDE7AKDM4E | |
| SCHEMBL7606302 | 0.79 | ITGB2 (0.68) | ITGB2ICAM1ITGALPDE7AKDM4E | |
| SCHEMBL7610177 | 0.79 | ITGB2 (0.79) | ITGB2ICAM1ITGALPDE7AKDM4E | |
| Hydrochloric Acid SCHEMBL7604738 | 0.78 | ITGB2 (0.77) | ITGB2ICAM1ITGALPDE7AKDM4E | |
| SCHEMBL7610151 | 0.76 | ITGB2 (0.74) | ITGB2ICAM1ITGALPDE7AKDM4E | |
| SCHEMBL2030464 | 0.75 | PDE7A (0.69) | ITGB2ICAM1ITGALPDE7AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |