SCHEMBL7607052

SCHEMBL7607052

COCc1cnc(C)nc1N

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 1.00
CYP1A2 P05177 1/20 0.47
TSHR P16473 1/20 0.47
TKT P29401 3/20 0.46
KDM4E B2RXH2 3/20 0.44
ALDH1A1 P00352 2/20 0.43
GAA P10253 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11388566 0.82 LMNA (0.70) LMNATSHRALDH1A1HTT
SCHEMBL7724215 0.81 LMNA (0.69) LMNACYP1A2TSHRTKTKDM4E
SCHEMBL20618234 0.80 LMNA (0.67) LMNACYP1A2TSHRTKTKDM4E
SCHEMBL11080074 0.79 LMNA (0.66) LMNATSHRKDM4EALDH1A1GAA
SCHEMBL11284274 0.79 LMNA (0.66) LMNATSHRKDM4EALDH1A1GAA
SCHEMBL18987265 0.79 LMNA (0.65) LMNACYP1A2TSHRTKTKDM4E
SCHEMBL11752565 0.78 LMNA (0.64) LMNAKDM4EALDH1A1GAAHPGD
SCHEMBL23748348 0.78 LMNA (0.63) LMNACYP1A2TSHRTKTKDM4E
SCHEMBL12346332 0.78 LMNA (0.63) LMNACYP1A2TSHRTKTKDM4E
SCHEMBL29895545 0.78 LMNA (0.63) LMNACYP1A2TSHRTKTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020040141-A1 Preparation of 2-methyl-4-amino-5-aminomethylpyrimidine BASF AKTIENGESELLSCHAFT (DE) 2002-04-04 US claimed
US-6365740-B1 REACTING 2-METHYL-4-AMINO-5-ALKOXYMETHYLPYRIMIDINE COMPOUND WITH AMMONIA IN PRESENCE OF CATALYST TO FORM 2-METHYL-4-AMINO-5-AMINOMETHYLPYRIMIDINE BASF AKTIENGESELLSCHAFT (DE) 2002-04-02 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020040141-A1 Preparation of 2-methyl-4-amino-5-aminomethylpyrimidine DPYD, DNMT1, TPMT LMNA 3550/4885CYP1A2 266/4885TSHR 4154/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.