Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PNP | P00491 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | NT5E | P21589 | 4/20 | 0.45 |
| ▸ | AHCY | P23526 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7608943 | 1.00 | TYMP (0.59) | TYMPLMNAPNPTP53HTT | |
| SCHEMBL22216348 | 0.91 | PNP (0.59) | TYMPLMNAPNPTP53HTT | |
| SCHEMBL20350582 | 0.91 | PNP (0.59) | TYMPLMNAPNPTP53HTT | |
| SCHEMBL1774839 | 0.88 | TYMP (0.63) | TYMPNT5EADORA1HIF1APOLB | |
| SCHEMBL29529385 | 0.88 | TYMP (0.63) | TYMPNT5EADORA1HIF1APOLB | |
| SCHEMBL1774838 | 0.88 | TYMP (0.63) | TYMPNT5EADORA1HIF1APOLB | |
| SCHEMBL7871248 | 0.88 | TYMP (0.63) | TYMPNT5EADORA1HIF1APOLB | |
| SCHEMBL29574745 | 0.88 | TYMP (0.63) | TYMPNT5EADORA1HIF1APOLB | |
| SCHEMBL30140978 | 0.86 | TYMP (0.45) | TYMPNT5EAHCYADORA1CA5A | |
| SCHEMBL7895839 | 0.86 | TYMP (0.69) | TYMPLMNANT5EADORA1CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4370136-A2 | SIMPLE CHEMICAL APPROACHES TO INTRODUCE 2,6-DIAMINOPURINE AND 2-AMINOADENINE CONJUGATES INTO OLIGONUCLEOTIDES | Alnylam Pharmaceuticals, Inc. (US) | 2024-05-22 | — | — | EP | disclosed |
| WO-2023288045-A2 | SIMPLE CHEMICAL APPROACHES TO INTRODUCE 2,6-DIAMINOPURINE AND 2-AMINOADENINE CONJUGATES INTO OLIGONUCLEOTIDES | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |
| EP-1198592-A4 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS INC (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1198592-A1 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS, INC. (US) | 2002-04-24 | — | — | EP | disclosed |
| US-6175004-B1 | REACTING AN OLIGONUCLEOTIDE COMPRISING A HALOGENATED PURINE NUCLEOSIDE WITH AMINE; FOR STRONGER HYBRIDIZATION; DIAGNOSIS; GENETIC ENGINEERING; ANTISENSE AGENTS | ISIS PHARMACEUTICALS, INC. | 2001-01-16 | — | — | US | disclosed |
| WO-2001002608-A1 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | disclosed |