SCHEMBL7607212

SCHEMBL7607212

O=C(O)c1ccc(-c2ccc(O)cc2)cc1F

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 3/20 0.56
RARA P10276 2/20 0.56
RARG P13631 1/20 0.56
HSD17B10 Q99714 2/20 0.53
KDM4E B2RXH2 1/20 0.53
LMNA P02545 1/20 0.53
HNF4A P41235 2/20 0.52
ACMSD Q8TDX5 2/20 0.52
AKR1C2 P52895 1/20 0.51
AKR1C1 Q04828 1/20 0.51
KIF11 P52732 1/20 0.50
CA12 O43570 1/20 0.48
ALDH1A1 P00352 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
TSHR P16473 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
DHFR P00374 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16534058 0.90 RARB (0.60) RARBRARARARGHSD17B10KDM4E
SCHEMBL30641680 0.90 RARB (0.60) RARBRARARARGHSD17B10KDM4E
SCHEMBL121429 0.86 ACMSD (0.63) RARBRARARARGHSD17B10KDM4E
SCHEMBL31725051 0.86 ACMSD (0.63) RARBRARARARGHSD17B10KDM4E
SCHEMBL4652842 0.86 RARB (0.58) RARBRARARARGHSD17B10KDM4E
SCHEMBL9939389 0.86 ESR1 (0.62) RARBRARARARGACMSDCA12
SCHEMBL29372732 0.86 RARB (0.57) RARBRARARARGHSD17B10KDM4E
SCHEMBL17177744 0.86 RARB (0.57) RARBRARARARGHSD17B10KDM4E
SCHEMBL28683577 0.85 KDM4E (0.68) RARBRARARARGHSD17B10KDM4E
SCHEMBL16534012 0.85 KDM4E (0.68) RARBRARARARGHSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0992486-B1 Tetralin compound, liquid crystal material, and liquid crystal composition MITSUI CHEMICALS INC (JP) 2002-11-20 EP disclosed
US-6117359-A A FERROELECTRIC LIQUID CRYSTAL, AN ANTIFERROELECTRIC LIQUID CRYSTAL; OPERATING WIDE TEMPERATURE RANGE, A HIGH SWITCHING SPEED AND A SMALL CONSUMPTION OF ELECTRIC POWER, A STABLE CONTRAST MITSUI CHEMICALS INC (JP) 2000-09-12 US disclosed
EP-0992486-A2 Tetralin compound, liquid crystal material, and liquid crystal composition Mitsui Chemicals, Inc. (JP) 2000-04-12 EP disclosed