Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 15/20 | 0.67 |
| ▸ | TUBB4A | P04350 | 9/20 | 0.67 |
| ▸ | TUBB | P07437 | 9/20 | 0.67 |
| ▸ | TUBA3C | P0DPH7 | 9/20 | 0.67 |
| ▸ | TUBA1B | P68363 | 9/20 | 0.67 |
| ▸ | TUBA4A | P68366 | 9/20 | 0.67 |
| ▸ | TUBB4B | P68371 | 9/20 | 0.67 |
| ▸ | TUBB3 | Q13509 | 9/20 | 0.67 |
| ▸ | TUBB2A | Q13885 | 9/20 | 0.67 |
| ▸ | TUBB8 | Q3ZCM7 | 9/20 | 0.67 |
| ▸ | TUBA3E | Q6PEY2 | 9/20 | 0.67 |
| ▸ | TUBA1A | Q71U36 | 9/20 | 0.67 |
| ▸ | TUBA1C | Q9BQE3 | 9/20 | 0.67 |
| ▸ | TUBB6 | Q9BUF5 | 9/20 | 0.67 |
| ▸ | TUBB2B | Q9BVA1 | 9/20 | 0.67 |
| ▸ | KRAS | P01116 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7607438 | 1.00 | TUBB1 (0.67) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7552543 | 0.88 | KRAS (0.55) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7552539 | 0.88 | KRAS (0.55) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7611033 | 0.86 | TUBB1 (0.62) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7611037 | 0.86 | TUBB1 (0.62) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7546465 | 0.86 | KRAS (0.55) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7546467 | 0.86 | KRAS (0.55) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6776585 | 0.85 | TUBB1 (0.73) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6776580 | 0.85 | TUBB1 (0.73) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6345748 | 0.85 | TUBB1 (0.71) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020143064-A1 | Novel use of compounds of the chalcones class | AVENTIS PHARMA S.A. (FR) | 2002-10-03 | — | — | US | claimed |
| US-20020143064-A1 | Novel use of compounds of the chalcones class | AVENTIS PHARMA S.A. (FR) | 2002-10-03 | — | — | US | disclosed |
| EP-0288794-B1 | Controlling the growth of tumor tissue with chalcone derivatives | MERRELL DOW PHARMA (US) | 1994-06-08 | — | — | EP | disclosed |
| EP-0286083-B1 | METHOD OF TREATING MULTIPLE SCLEROSIS WITH CHALCONE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-04 | — | — | EP | disclosed |
| EP-0287901-B1 | METHODS FOR TREATING GOUT WITH CHALCONE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4904697-A | Controlling the growth of certain tumor tissue with chalcone derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4863968-A | Methods of treating gout with chalcone derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4753965-A | INHIBITING DESTRUCTION OF MYELIN SHEATH; ANTIMITOTIC | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020143064-A1 | Novel use of compounds of the chalcones class | NR2E1, FLT1, KDR | TUBB1 304/4885TUBB4A 408/4885TUBB 532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.