Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estriol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 6/20 | 0.73 |
| ▸ | ESR2 known ✓ | Q92731 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | PGR | P06401 | 3/20 | 0.73 |
| ▸ | AR | P10275 | 3/20 | 0.73 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.73 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.73 |
| ▸ | SHBG | P04278 | 1/20 | 0.73 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.73 |
| ▸ | SNCA | P37840 | 1/20 | 0.73 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.73 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5527386 | 0.96 | MAPT (0.72) | ESR1LMNAPGRARESR2 | |
| Estriol SCHEMBL5527393 | 0.88 | ESR1 (0.83) | ESR1LMNAPGRARESR2 | |
| Estriol SCHEMBL6331811 | 0.88 | ESR1 (0.83) | ESR1LMNAPGRARESR2 | |
| SCHEMBL6331808 | 0.87 | MAPT (0.73) | ESR1LMNAPGRARESR2 | |
| SCHEMBL32662774 | 0.87 | MAPT (0.73) | ESR1LMNAPGRARESR2 | |
| SCHEMBL4585647 | 0.87 | MAPT (0.62) | ESR1LMNAPGRARESR2 | |
| SCHEMBL11207655 | 0.86 | MAPT (0.66) | ESR1LMNAPGRARESR2 | |
| SCHEMBL345505 | 0.86 | MAPT (0.66) | ESR1LMNAPGRARESR2 | |
| SCHEMBL10349423 | 0.86 | MAPT (0.74) | ESR1LMNAPGRARESR2 | |
| SCHEMBL21523187 | 0.86 | ESR1 (0.67) | ESR1LMNAPGRARESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020094951-A1 | DENTAL REMEDIES CONTAINING PTH | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-18 | — | — | US | disclosed |