SCHEMBL7607938

SCHEMBL7607938

O=C(NC(=O)c1c(Cl)cccc1Cl)Nc1ccc(Br)c(F)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.48
KMT2A Q03164 5/20 0.48
MAPT P10636 5/20 0.48
MEN1 O00255 4/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
LMNA P02545 2/20 0.48
HTT P42858 2/20 0.48
RAB9A P51151 5/20 0.46
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
MAPK1 P28482 1/20 0.44
SLC2A1 P11166 1/20 0.43
PYGL P06737 1/20 0.43
MAOB P27338 1/20 0.43
PPIA P62937 1/20 0.43
TLR7 Q9NYK1 1/20 0.42
GAA P10253 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
NFKB1 P19838 1/20 0.42
NFKB2 Q00653 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30499699 1.00 NPC1 (0.48) NPC1KMT2AMAPTMEN1SMN1; SMN2
SCHEMBL7603173 0.89 KMT2A (0.52) NPC1KMT2AMAPTMEN1SMN1; SMN2
SCHEMBL30499669 0.88 KMT2A (0.62) NPC1KMT2AMAPTMEN1SMN1; SMN2
SCHEMBL7605671 0.88 SLC2A1 (0.50) NPC1KMT2AMAPTMEN1SMN1; SMN2
SCHEMBL7602876 0.88 NPC1 (0.50) NPC1KMT2AMAPTMEN1SMN1; SMN2
SCHEMBL7603203 0.88 KMT2A (0.62) NPC1KMT2AMAPTMEN1SMN1; SMN2
SCHEMBL30499679 0.88 NPC1 (0.50) NPC1KMT2AMAPTMEN1SMN1; SMN2
SCHEMBL9348738 0.85 MAPT (0.48) NPC1KMT2AMAPTMEN1SMN1; SMN2
SCHEMBL7602947 0.84 MEN1 (0.47) NPC1KMT2AMAPTMEN1SMN1; SMN2
SCHEMBL30499693 0.84 MEN1 (0.47) NPC1KMT2AMAPTMEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190254281-A1 ENHANCED YIELD IN NUT BEARING PLANTS UPL CORPORATION LTD. (MU) 2019-08-22 US claimed
WO-2019161274-A1 ENHANCED YIELD IN NUT BEARING PLANTS UPL CORPORATION LTD. (MU) 2019-08-22 WO claimed
US-6376430-B1 APPLYING TO CROP UNIROYAL CHEMICAL COMPANY, INC. 2002-04-23 US claimed
WO-1999016316-A1 ENHANCEMENT OF SEED YIELD OF SOYBEANS BY A SUBSTITUTED BENZOYL UREA UNIROYAL CHEMICAL COMPANY, INC. (US) 1999-04-08 WO claimed
WO-1997045017-A1 BENZOYLUREA INSECTICIDES ON GENE-MODIFIED Bt COTTON UNIROYAL CHEMICAL COMPANY, INC. (US) 1997-12-04 WO claimed
US-4243680-A N-(2,6-DIHALOBENZOYL)-N'-(HALOGENATED PHENYL) UREA; LARVICIDES THOMPSON-HAYWARD CHEMICAL COMPANY (US) 1981-01-06 US claimed
US-11641859-B2 Enhanced yield in nut bearing plants UPL CORPORATION LTD. (MU) 2023-05-09 US disclosed
US-20190254281-A1 ENHANCED YIELD IN NUT BEARING PLANTS UPL CORPORATION LTD. (MU) 2019-08-22 US disclosed
WO-2019161274-A1 ENHANCED YIELD IN NUT BEARING PLANTS UPL CORPORATION LTD. (MU) 2019-08-22 WO disclosed
US-6376430-B1 APPLYING TO CROP UNIROYAL CHEMICAL COMPANY, INC. 2002-04-23 US disclosed
US-6242385-B1 SEEDS OF LEGUME PLANTS, APPLYING TO FOLAGE DURING REPRODUCTION PHENYLUREA DERIVATIVES UNIROYAL CHEMICAL COMPANY, INC. 2001-06-05 US disclosed
US-6057370-A APPLYING TO THE FOLIAGE OF SAID GENETICALLY ALTERED COTTON PLANT AN ENHANCED PESTICIDALLY ACTIVE AMOUNT OF A SUBSTITUTED BENZOYL UREA MACDERMID AGRICULTURAL SOLUTIONS, INC. 2000-05-02 US disclosed
WO-1999016316-A1 ENHANCEMENT OF SEED YIELD OF SOYBEANS BY A SUBSTITUTED BENZOYL UREA UNIROYAL CHEMICAL COMPANY, INC. (US) 1999-04-08 WO disclosed
US-4607044-A Insecticidal use of ureas and thioureas DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1986-08-19 US disclosed
US-4243680-A N-(2,6-DIHALOBENZOYL)-N'-(HALOGENATED PHENYL) UREA; LARVICIDES THOMPSON-HAYWARD CHEMICAL COMPANY (US) 1981-01-06 US disclosed
US-4166124-A IMIDAZOLE OR PYRIMIDINE RINGS U.S. PHILIPS CORPORATION (US) 1979-08-28 US disclosed
US-4110469-A Insecticidal N-(2,6-dichlorobenzoyl)-N'-(4-cyanophenyl) urea U.S. PHILIPS CORPORATION (US) 1978-08-29 US disclosed
US-4013717-A BENZOYL PHENYL UREA DERIVATIVES HAVING INSECTICIDAL ACTIVITIES U.S. PHILIPS CORPORATION (US) 1977-03-22 US disclosed
US-3989842-A Certain substituted benzoyl urea insecticides U.S. PHILIPS CORPORATION (US) 1976-11-02 US disclosed
US-3933908-A INSECTICIDE U.S. PHILIPS CORPORATION (US) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190254281-A1 ENHANCED YIELD IN NUT BEARING PLANTS NUTF2, MYCBP, MYCBP2 NPC1 1857/4885KMT2A 2393/4885MAPT 1882/4885
US-11641859-B2 Enhanced yield in nut bearing plants NUTF2, MYCBP, MYCBP2 NPC1 1857/4885KMT2A 2393/4885MAPT 1882/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.