Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605224 | 0.90 | SIGMAR1 (0.47) | SIGMAR1HSD11B1HRH2HRH1ALDH1A1 | |
| SCHEMBL6675771 | 0.87 | SIGMAR1 (0.45) | SIGMAR1HSD11B1HRH2HRH1ALDH1A1 | |
| SCHEMBL7612560 | 0.87 | SIGMAR1 (0.46) | SIGMAR1HSD11B1HRH2HRH1ALDH1A1 | |
| SCHEMBL7047217 | 0.85 | SIGMAR1 (0.48) | SIGMAR1HSD11B1HRH2HRH1ALDH1A1 | |
| SCHEMBL7611938 | 0.84 | SIGMAR1 (0.46) | SIGMAR1HSD11B1HRH2HRH1ALDH1A1 | |
| SCHEMBL7637370 | 0.84 | SIGMAR1 (0.42) | SIGMAR1HSD11B1 | |
| SCHEMBL7613302 | 0.84 | SIGMAR1 (0.43) | SIGMAR1HSD11B1HRH2HRH1ALDH1A1 | |
| SCHEMBL7607801 | 0.84 | SIGMAR1 (0.53) | SIGMAR1HSD11B1HRH2HRH1ALDH1A1 | |
| SCHEMBL7613371 | 0.84 | SIGMAR1 (0.47) | SIGMAR1HSD11B1HRH2HRH1ALDH1A1 | |
| SCHEMBL7608405 | 0.83 | SIGMAR1 (0.52) | SIGMAR1HSD11B1HRH2HRH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259492-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES AS MTP INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001047899-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES AS MTP INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |