Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 8/20 | 0.55 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.49 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6037818 | 0.89 | FOLH1 (0.47) | FOLH1GRM3NAALAD2 | |
| SCHEMBL5057914 | 0.87 | GRM3 (0.63) | FOLH1GRM3NAALAD2 | |
| SCHEMBL10901126 | 0.81 | LMNA (0.43) | — | |
| SCHEMBL8063534 | 0.79 | FOLH1 (0.58) | FOLH1GRM3NAALAD2SMN1; SMN2 | |
| SCHEMBL8065592 | 0.79 | FOLH1 (0.50) | FOLH1GRM3NAALAD2 | |
| SCHEMBL7608702 | 0.76 | FOLH1 (0.72) | FOLH1GRM3NAALAD2 | |
| SCHEMBL6037781 | 0.73 | FOLH1 (0.50) | FOLH1GRM3NAALAD2 | |
| SCHEMBL8060048 | 0.72 | FOLH1 (1.00) | FOLH1GRM3NAALAD2 | |
| SCHEMBL5379957 | 0.72 | METAP1 (0.41) | — | |
| SCHEMBL2951190 | 0.72 | METAP1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514184-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-1005348-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1998013046-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |