Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 9/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.32 |
| ▸ | CBLB | Q13191 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5648745 | 0.77 | SLC6A2 (0.70) | NOS2CYP2D6SLC6A2SLC6A4KCNH2 | |
| Hydrochloric Acid SCHEMBL5650489 | 0.76 | SLC6A2 (0.68) | NOS2CYP2D6SLC6A2SLC6A4KCNH2 | |
| SCHEMBL27513304 | 0.75 | NOS2 (0.59) | NOS2CYP2D6SLC6A2SLC6A4KCNH2 | |
| SCHEMBL6494143 | 0.74 | SLC6A4 (0.72) | NOS2CYP2D6SLC6A2SLC6A4KCNH2 | |
| SCHEMBL7607981 | 0.74 | NOS2 (0.38) | NOS2CYP2D6SLC6A2SLC6A4KCNH2 | |
| Hydrochloric Acid SCHEMBL27526759 | 0.74 | NOS2 (0.60) | NOS2CYP2D6SLC6A2SLC6A4KCNH2 | |
| SCHEMBL6278719 | 0.74 | CYP2D6 (0.41) | NOS2CYP2D6SLC6A2SLC6A4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6496956 | 0.74 | SLC6A4 (0.71) | NOS2CYP2D6SLC6A2SLC6A4KCNH2 | |
| SCHEMBL5653417 | 0.72 | NOS2 (0.81) | NOS2CYP2D6SLC6A2SLC6A4KCNH2 | |
| Hydrochloric Acid SCHEMBL5652171 | 0.71 | NOS2 (0.79) | NOS2CYP2D6SLC6A2SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263718-A1 | NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | claimed |
| WO-2001062721-A1 | NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | claimed |
| EP-1263718-A1 | NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001062721-A1 | NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |