Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5129787 | 0.95 | METAP1 (0.47) | METAP1KMT2AJAK2PPP1CATDP1 | |
| SCHEMBL5128120 | 0.91 | MEN1 (0.45) | KMT2AL3MBTL1NPC1RAB9AHIF1A | |
| SCHEMBL7611754 | 0.89 | METAP1 (0.47) | METAP1KMT2AJAK2PPP1CATDP1 | |
| SCHEMBL7610471 | 0.89 | METAP1 (0.47) | METAP1KMT2AJAK2PPP1CATDP1 | |
| SCHEMBL7617807 | 0.89 | ADORA2A (0.39) | METAP1KMT2AJAK2PPP1CATDP1 | |
| SCHEMBL7611579 | 0.87 | METAP1 (0.45) | METAP1KMT2AJAK2PPP1CATDP1 | |
| SCHEMBL7611837 | 0.85 | METAP1 (0.43) | METAP1KMT2AJAK2PPP1CATDP1 | |
| SCHEMBL5116032 | 0.85 | USP1 (0.50) | KMT2AL3MBTL1NPC1HIF1AMAPK1 | |
| SCHEMBL5128041 | 0.85 | METAP1 (0.65) | METAP1KMT2AJAK2PPP1CATDP1 | |
| SCHEMBL7613329 | 0.84 | PRKCI (0.48) | NPC1RAB9AMAPK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432950-B1 | ANTICANCER AGENTS; KILLING CANCER CELLS | CELL PATHWAYS | 2002-08-13 | — | — | US | disclosed |
| US-6133271-A | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives | CELL PATHWAYS, INC. (US) | 2000-10-17 | — | — | US | disclosed |