Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT1 | P24752 | 1/20 | 0.70 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.68 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7612035 | 0.99 | ACAT1 (0.71) | ACAT1SOAT1AVPR1B | |
| SCHEMBL7633066 | 0.97 | ACAT1 (0.70) | ACAT1SOAT1AVPR1B | |
| SCHEMBL7618247 | 0.95 | ACAT1 (0.70) | ACAT1SOAT1AVPR1B | |
| SCHEMBL7616210 | 0.94 | ACAT1 (0.68) | ACAT1SOAT1AVPR1B | |
| SCHEMBL6638040 | 0.93 | ACAT1 (0.73) | ACAT1SOAT1AVPR1B | |
| SCHEMBL6633600 | 0.93 | ACAT1 (0.74) | ACAT1SOAT1AVPR1B | |
| SCHEMBL6636996 | 0.91 | ACAT1 (0.73) | ACAT1SOAT1AVPR1B | |
| SCHEMBL7610570 | 0.90 | ACAT1 (0.73) | ACAT1SOAT1AVPR1B | |
| SCHEMBL6636733 | 0.90 | ACAT1 (0.62) | ACAT1SOAT1AVPR1B | |
| SCHEMBL8328835 | 0.88 | ACAT1 (0.66) | ACAT1SOAT1AVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420381-B1 | ACYL-COA: CHOLESTEROL ACYL TRANSFERASE (ACAT) INHIBITORY ACTIVITY, AND IS USEFUL AS AN AGENT FOR TREATMENT OF HYPERLIPIDEMIA AND ATHEROSCLEROSIS. | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1104763-A1 | NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-06 | — | — | EP | disclosed |