Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR | P34981 | 2/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.30 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.30 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.30 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.30 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.30 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL6903283 | 0.95 | TRHR (0.34) | TRHRITGA4ITGB1 | |
| Histidine SCHEMBL2586203 | 0.91 | SLC7A5 (0.35) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| D-Histidine SCHEMBL11606906 | 0.91 | SLC7A5 (0.35) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| Histidine SCHEMBL2586200 | 0.91 | SLC7A5 (0.35) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| Histidine SCHEMBL27902238 | 0.91 | SLC7A5 (0.35) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| Histidine SCHEMBL16444321 | 0.89 | CYP3A4 (0.32) | GRIA1GRIA2GRIA3GRIA4 | |
| Histidine SCHEMBL10828038 | 0.87 | CYP1A2 (0.33) | ITGA4GRIK1GRIK2GRIK3GRIK4 | |
| Histidine SCHEMBL3088582 | 0.87 | CYP3A4 (0.32) | — | |
| Histidine SCHEMBL3490081 | 0.87 | CYP3A4 (0.32) | — | |
| Histidine SCHEMBL1675273 | 0.87 | CYP3A4 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020177558-A1 | METHOD OF TREATING, PREVENTING OR INHIBITING CENTRAL NERVOUS SYSTEM INJURIES AND DISEASES | ARMY, UNITED STATES | 2002-11-28 | — | — | US | disclosed |
| US-6469049-B1 | Administering a lipoic acid compound, such as alpha-lipoic acid, dihydrolipoic acid, or 2-(N,N-dimethylamino)ethylamido lipoate-HCL. | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2002-10-22 | — | — | US | disclosed |
| WO-2001080851-A1 | METHOD OF TREATING, PREVENTING OR INHIBITING CENTRAL NERVOUS SYSTEM INJURIES AND DISEASES | UNITED STATES ARMY MEDICAL RESEARCH AND MATERIEL COMMAND (US) | 2001-11-01 | — | — | WO | disclosed |