Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | SGK1 | O00141 | 3/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7609945 | 1.00 | GAA (0.43) | GAANOD2GUSBALDH1A1MAPT | |
| SCHEMBL5866378 | 0.89 | GAA (0.46) | GAANOD2GUSBALDH1A1MAPT | |
| SCHEMBL5866368 | 0.89 | GAA (0.46) | GAANOD2GUSBALDH1A1MAPT | |
| SCHEMBL7609950 | 0.85 | GAA (0.43) | GAANOD2GUSBALDH1A1MAPT | |
| SCHEMBL5866291 | 0.78 | NOD2 (0.47) | NOD2GUSBACLY | |
| SCHEMBL5866287 | 0.78 | NOD2 (0.47) | NOD2GUSBACLY | |
| SCHEMBL5866205 | 0.75 | GUSB (0.55) | GAANOD2GUSBALDH1A1MAPT | |
| SCHEMBL5866211 | 0.75 | GUSB (0.55) | GAANOD2GUSBALDH1A1MAPT | |
| SCHEMBL7609955 | 0.75 | GAA (0.44) | GAANOD2GUSBALDH1A1MAPT | |
| SCHEMBL5866372 | 0.74 | GAA (0.46) | GAANOD2GUSBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0917528-B1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-18 | — | — | EP | disclosed |