SCHEMBL7609991

SCHEMBL7609991

CSCCC(N)C(=O)NC(Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NPY1R P25929 1/20 0.53
NPY2R P49146 1/20 0.53
NPY4R P50391 1/20 0.53
MME P08473 4/20 0.53
ACE P12821 2/20 0.53
CPA1 P15085 1/20 0.53
ACE2 Q9BYF1 1/20 0.53
FOLH1 Q04609 1/20 0.51
NAALAD2 Q9Y3Q0 1/20 0.51
FNTA P49354 3/20 0.50
FNTB P49356 3/20 0.50
PGGT1B P53609 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7609995 1.00 NPY1R (0.53) NPY1RNPY2RNPY4RMMEACE
SCHEMBL29558363 0.93 ENPEP (0.52) NPY1RNPY2RNPY4RMMEACE
SCHEMBL30311095 0.91 ENPEP (0.57) NPY1RNPY2RNPY4RNAALAD2FNTA
SCHEMBL29794193 0.90 FNTA (0.55) FNTAFNTBPGGT1B
SCHEMBL21828645 0.90 FNTA (0.55) FNTAFNTBPGGT1B
SCHEMBL2549632 0.90 FNTA (0.55) FNTAFNTBPGGT1B
SCHEMBL26417444 0.90 NPY4R (0.53) NPY1RNPY2RNPY4RACE
SCHEMBL13154780 0.90 FNTA (0.60) MMEFNTAFNTBPGGT1B
SCHEMBL9442969 0.90 FNTA (0.60) MMEFNTAFNTBPGGT1B
SCHEMBL10696437 0.90 FNTA (0.60) MMEFNTAFNTBPGGT1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020071258-A1 PROTEIN GLYCATION SUPPRESSANT 味の素株式会社 2020-04-09 WO disclosed
EP-0678522-B1 Insulin analogs LILLY CO ELI (US) 2002-01-02 EP disclosed
US-5700662-A CULTURING A GENETIC ENGINEERED HOST CELL, GENE EXPRESSING A DNA, ENCODING A PROINSULIN, ENZYMATICALLY DISCONNECTING ELI LILLY AND COMPANY (US) 1997-12-23 US disclosed
US-5514646-A AND OPTIONALLY AT OTHER POSITIONS; USE TO TREAT HYPERGLYCEMIA ELI LILLY AND COMPANY 1996-05-07 US disclosed
EP-0383472-B1 Insulin analogs LILLY CO ELI (US) 1996-02-07 EP disclosed
EP-0678522-A1 Insulin analogs ELI LILLY AND COMPANY (US) 1995-10-25 EP disclosed
EP-0383472-A2 Insulin analogs ELI LILLY AND COMPANY (US) 1990-08-22 EP disclosed
EP-0127108-B1 PROCESS FOR PREPARING POLYPEPTIDES MERCK & CO. INC. (US) 1986-12-30 EP disclosed
US-4510083-A POTASSIUM, CESIUM OR RUBIDIUM CARBONATE BUFFER FOR COUPLING OF AMINO ACID N-CARBOXYANHYDRIDE WITH ANOTHER AMINO ACID OR PEPTIDE MERCK & CO., INC. (US) 1985-04-09 US disclosed
EP-0127108-A1 Process for preparing polypeptides MERCK & CO. INC. (US) 1984-12-05 EP disclosed