Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.39 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | F13A1 | P00488 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3500893 | 0.98 | KDM4E (0.40) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| Bromide SCHEMBL7611201 | 0.98 | KDM4E (0.40) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL7610185 | 0.96 | KDM4E (0.41) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL7612933 | 0.87 | KDM4E (0.47) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| Bromide SCHEMBL7613738 | 0.87 | KDM4E (0.47) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| Bromide SCHEMBL7619298 | 0.86 | HIF1A (0.50) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL7613702 | 0.85 | KDM4E (0.48) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL7615499 | 0.84 | HIF1A (0.52) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL11409292 | 0.70 | GRIN2D (0.30) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL21197516 | 0.69 | MAPK1 (0.50) | KDM4EMAPK1HIF1AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888293-B1 | N-ACYLAMINOALKYLHYDRAZINECARBOXIMIDAMIDES | ALTEON INC (US) | 2002-03-27 | — | — | EP | claimed |