Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 8/20 | 0.55 |
| ▸ | ICAM1 | P05362 | 8/20 | 0.55 |
| ▸ | ITGAL | P20701 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196912 | 0.86 | ITGB2 (0.57) | ITGB2ICAM1ITGALRAB9AKDM4E | |
| SCHEMBL6197072 | 0.80 | ITGB2 (0.55) | ITGB2ICAM1ITGALRAB9AKDM4E | |
| SCHEMBL5830524 | 0.79 | ITGB2 (0.72) | ITGB2ICAM1ITGALRAB9ACYP1A2 | |
| SCHEMBL6198618 | 0.79 | ITGB2 (0.63) | ITGB2ICAM1ITGALRAB9AKMT2A | |
| SCHEMBL5829930 | 0.74 | ITGB2 (0.70) | ITGB2ICAM1ITGALRAB9AKDM4E | |
| SCHEMBL6317156 | 0.73 | ITGB2 (0.66) | ITGB2ICAM1ITGALRAB9AKDM4E | |
| SCHEMBL5830254 | 0.73 | ITGB2 (0.70) | ITGB2ICAM1ITGALRAB9ACYP1A2 | |
| SCHEMBL6220488 | 0.72 | ITGB2 (0.49) | ITGB2ICAM1ITGALRAB9ACYP1A2 | |
| SCHEMBL5830373 | 0.71 | ITGB2 (0.56) | ITGB2ICAM1ITGALRAB9AKDM4E | |
| SCHEMBL6309487 | 0.71 | ITGB2 (0.58) | ITGB2ICAM1ITGALRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140814-A2 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000039081-A2 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-07-06 | — | — | WO | claimed |
| EP-1165505-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1140814-A2 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000059880-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-10-12 | — | — | WO | disclosed |
| WO-2000039081-A2 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-07-06 | — | — | WO | disclosed |