Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7612008 | 0.84 | KMT2A (0.60) | ATMRAB9AKMT2ASMN1; SMN2POLB | |
| SCHEMBL7614096 | 0.80 | ATM (0.69) | ATMRAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7620949 | 0.80 | ATM (0.69) | ATMRAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7617068 | 0.80 | RAB9A (0.58) | ATMRAB9AALDH1A1SMN1; SMN2EPHX2 | |
| SCHEMBL7613507 | 0.79 | ATM (0.67) | ATMRAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7615703 | 0.77 | EPHX1 (0.60) | ATMRAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7609575 | 0.75 | NOX1 (0.60) | RAB9AKMT2AALDH1A1NOX1FPR2 | |
| SCHEMBL2752680 | 0.72 | EPHX1 (0.68) | RAB9AKMT2AALDH1A1SMN1; SMN2EPHX2 | |
| SCHEMBL7612631 | 0.71 | NOX1 (0.51) | RAB9AKMT2AALDH1A1SMN1; SMN2NOX1 | |
| SCHEMBL5534712 | 0.70 | RAB9A (0.64) | ATMRAB9AKMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777471-B1 | INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES | MINNESOTA MINING & MFG (US) | 2002-11-27 | — | — | EP | claimed |
| EP-0777471-A1 | INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-06-11 | — | — | EP | claimed |
| WO-1996003983-A1 | INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-02-15 | — | — | WO | claimed |
| EP-0777471-B1 | INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES | MINNESOTA MINING & MFG (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-0777471-A1 | INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-06-11 | — | — | EP | disclosed |
| US-5612377-A | OXYUREA DERIVATIVE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| WO-1996003983-A1 | INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-02-15 | — | — | WO | disclosed |