Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132012 | 0.82 | MAPT (0.45) | BRD4CREBBPEGFRHSPA1APTPN7 | |
| SCHEMBL1043937 | 0.82 | MAPT (0.45) | BRD4CREBBPEGFRHSPA1APTPN7 | |
| SCHEMBL4135246 | 0.81 | BRD4 (0.40) | BRD4CREBBPMEN1ALOX15KMT2A | |
| SCHEMBL4135241 | 0.81 | BRD4 (0.40) | BRD4CREBBPMEN1ALOX15KMT2A | |
| SCHEMBL4127974 | 0.81 | BRD4 (0.40) | BRD4CREBBPMEN1ALOX15KMT2A | |
| SCHEMBL4127978 | 0.81 | BRD4 (0.40) | BRD4CREBBPMEN1ALOX15KMT2A | |
| SCHEMBL4127983 | 0.81 | BRD4 (0.40) | BRD4CREBBPMEN1ALOX15KMT2A | |
| SCHEMBL6360641 | 0.78 | HSD17B2 (0.48) | HSD17B2PTGDR2 | |
| SCHEMBL3197354 | 0.78 | HSD17B2 (0.48) | HSD17B2PTGDR2 | |
| SCHEMBL18407438 | 0.73 | BRD4 (0.46) | BRD4CREBBPMTNR1AMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1402711-A | 4-carboxyamino-2-ethyl-1, 2,3, 4-tetrahydroquinoline crystals as CETP inhibitors | PFIZER PROD INC (US) | 2003-03-12 | — | — | CN | disclosed |
| EP-1246804-A1 | 4-CARBOXYAMINO-2-ETHYL-1,2,3,4-TETRAHYDROQUINOLINE CRYSTAL AS CETP INHIBITOR | Pfizer Products Inc. (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1246804-A1 | 4-CARBOXYAMINO-2-ETHYL-1,2,3,4-TETRAHYDROQUINOLINE CRYSTAL AS CETP INHIBITOR | Pfizer Products Inc. (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001040190-A1 | 4-CARBOXYAMINO-2-ETHYL-1,2,3,4-TETRAHYDROQUINOLINE CRYSTAL AS CETP INHIBITOR | PFIZER PRODUCTS INC. (US) | 2001-06-07 | — | — | WO | disclosed |
| WO-2001040190-A1 | 4-CARBOXYAMINO-2-ETHYL-1,2,3,4-TETRAHYDROQUINOLINE CRYSTAL AS CETP INHIBITOR | PFIZER PRODUCTS INC. (US) | 2001-06-07 | — | — | WO | disclosed |