Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | RGS4 | P49798 | 1/20 | 0.40 |
| ▸ | RGS8 | P57771 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352063 | 0.85 | BRD4 (0.42) | KMT2ABRD4SMN1; SMN2SIGMAR1RGS4 | |
| SCHEMBL10460973 | 0.81 | BRD4 (0.39) | BRD4SMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7613547 | 0.80 | ELANE (0.50) | KMT2ABRD4ALDH1A1L3MBTL1 | |
| SCHEMBL7607390 | 0.79 | BRD4 (0.51) | BRD4 | |
| SCHEMBL11204308 | 0.79 | BRD4 (0.48) | KMT2ABRD4POLBDBH | |
| SCHEMBL29481371 | 0.79 | BRD4 (0.48) | KMT2ABRD4POLBDBH | |
| Clomazone SCHEMBL27601346 | 0.77 | BRD4 (0.52) | KMT2ABRD4SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL11192742 | 0.77 | BRD4 (0.47) | KMT2ABRD4CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7614881 | 0.76 | BRD4 (0.56) | BRD4POLBSIGMAR1ALDH1A1TDP1 | |
| SCHEMBL29366872 | 0.76 | BRD4 (0.56) | BRD4POLBSIGMAR1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002534440-A | — | — | 2002-10-15 | — | — | JP | claimed |
| CN-1342078-A | Use of 3-isoxazolidinones and hydroxylamine acids for treatment of infections | JOMAA PHARMA GMBH (DE) | 2002-03-27 | — | — | CN | claimed |
| EP-1143941-A3 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | Jomaa Pharmaka GmbH (DE) | 2002-02-06 | — | — | EP | claimed |
| EP-1143941-A2 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | Jomaa Pharmaka GmbH (DE) | 2001-10-17 | — | — | EP | claimed |
| WO-2000041473-A2 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | JOMAA PHARMAKA GMBH (DE) | 2000-07-20 | — | — | WO | claimed |
| US-4405357-A | Herbicidal 3-isoxazolidinones and hydroxamic acids | FMC CORPORATION (US) | 1983-09-20 | — | — | US | disclosed |