Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | TIMP3 | P35625 | 4/20 | 0.69 |
| ▸ | RECQL | P46063 | 4/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | USP2 | O75604 | 2/20 | 0.69 |
| ▸ | HPSE | Q9Y251 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | PKM | P14618 | 3/20 | 0.60 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.60 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.60 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.60 |
| ▸ | ENTPD3 | O75355 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | TDP2 | O95551 | 1/20 | 0.60 |
| ▸ | CBX7 | O95931 | 1/20 | 0.60 |
| ▸ | NSD2 | O96028 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30388456 | 1.00 | KMT2A (0.69) | KMT2ATDP1MEN1TIMP3RECQL | |
| SCHEMBL30388503 | 0.95 | KMT2A (0.75) | KMT2ATDP1MEN1TIMP3RECQL | |
| SCHEMBL18136600 | 0.93 | TIMP3 (0.73) | KMT2ATDP1MEN1TIMP3RECQL | |
| SCHEMBL6362876 | 0.93 | KMT2A (0.73) | KMT2ATDP1MEN1TIMP3RECQL | |
| SCHEMBL10413406 | 0.92 | MEN1 (0.58) | KMT2ATDP1MEN1TIMP3RECQL | |
| SCHEMBL17903244 | 0.91 | HPSE (0.59) | KMT2ATDP1MEN1TIMP3RECQL | |
| SCHEMBL11593396 | 0.90 | TIMP3 (0.63) | KMT2ATDP1MEN1TIMP3RECQL | |
| SCHEMBL11762076 | 0.89 | KMT2A (0.60) | KMT2ATDP1MEN1TIMP3RECQL | |
| SCHEMBL17903278 | 0.88 | P2RY11 (0.60) | KMT2ATDP1MEN1TIMP3RECQL | |
| SCHEMBL17903262 | 0.88 | KMT2A (0.55) | KMT2ATDP1MEN1TIMP3RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6348464-B1 | Pyrrolecarbonylimino derivatives as naaladase inhibitors | GUILFORD PHARMACEUTICALS, INC. | 2002-02-19 | — | — | US | disclosed |
| WO-2001034596-A2 | PYRROLECARBONYLIMINO DERIVATIVES AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2001-05-17 | — | — | WO | disclosed |
| EP-0008154-A1 | Ureylene phenylene anionic naphthalene-sulfonic acids, their use as complement system inhibitors in a body fluid and process for their preparation | AMERICAN CYANAMID COMPANY (US) | 1980-02-20 | — | — | EP | disclosed |