Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT1 | P24752 | 1/20 | 0.46 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640973 | 0.91 | ACAT1 (0.52) | ACAT1SOAT1EDNRB | |
| SCHEMBL6638660 | 0.88 | ACAT1 (0.49) | ACAT1SOAT1EDNRBMAPTTHRB | |
| SCHEMBL6636150 | 0.86 | EDNRB (0.49) | ACAT1SOAT1EDNRBMAPTTHRB | |
| SCHEMBL6635742 | 0.86 | SOAT1 (0.45) | ACAT1SOAT1EDNRBMAPTTHRB | |
| SCHEMBL6634385 | 0.85 | EDNRB (0.46) | ACAT1SOAT1EDNRBMAPTTHRB | |
| SCHEMBL6639134 | 0.84 | EDNRB (0.44) | ACAT1SOAT1EDNRBMAPTTHRB | |
| SCHEMBL7734565 | 0.83 | ACAT1 (0.53) | ACAT1SOAT1MAPTTHRB | |
| SCHEMBL6634147 | 0.82 | DHODH (0.45) | EDNRBMAPTTHRBALDH1A1 | |
| SCHEMBL7735514 | 0.81 | ACAT1 (0.50) | ACAT1SOAT1ALDH1A1 | |
| SCHEMBL8330484 | 0.81 | ACAT1 (0.67) | ACAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420381-B1 | ACYL-COA: CHOLESTEROL ACYL TRANSFERASE (ACAT) INHIBITORY ACTIVITY, AND IS USEFUL AS AN AGENT FOR TREATMENT OF HYPERLIPIDEMIA AND ATHEROSCLEROSIS. | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1104763-A1 | NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-06 | — | — | EP | disclosed |