Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | KDM5A | P29375 | 3/20 | 0.40 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 2/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29263636 | 1.00 | SIGMAR1 (0.60) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL7615078 | 1.00 | SIGMAR1 (0.60) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL29273205 | 1.00 | SIGMAR1 (0.60) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL11022414 | 1.00 | SIGMAR1 (0.60) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL5883485 | 1.00 | SIGMAR1 (0.60) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL7614811 | 1.00 | SIGMAR1 (0.60) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL7619522 | 1.00 | SIGMAR1 (0.60) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL7613945 | 1.00 | SIGMAR1 (0.60) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL7618517 | 1.00 | SIGMAR1 (0.60) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL2111227 | 1.00 | SIGMAR1 (0.60) | SIGMAR1CYP1A2KDM5APHF8KDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1105558-C | 2,2-dichloroalkane carboxylic acids, process for preparing the same, medicament containing the same and use for treating insulin resistance | ROCHE DIAGNOSTICS GMBH (DE) | 2003-04-16 | — | — | CN | disclosed |
| EP-0790824-B1 | 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE | ROCHE DIAGNOSTICS GMBH (DE) | 2002-02-06 | — | — | EP | disclosed |
| US-5968982-A | TREATMENT OF DIABETES | ROCHE DIAGNOSTICS GMBH (DE) | 1999-10-19 | — | — | US | disclosed |
| CN-1171050-A | 2, 2-Dichloroalkanecarboxylic acids, method for the production thereof, medicaments containing the same and use thereof for the treatment of insulin resistance | BOEHRINGER MANNHEIM GMBH (DE) | 1998-01-21 | — | — | CN | disclosed |
| EP-0790824-A1 | 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE | Roche Diagnostics GmbH (DE) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015784-A2 | 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE | BOEHRINGER MANNHEIM GMBH (DE) | 1996-05-30 | — | — | WO | disclosed |