Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 9/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 7/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 7/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.77 |
| ▸ | PGR | P06401 | 4/20 | 0.77 |
| ▸ | AR | P10275 | 3/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | APEX1 | P27695 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Beclomethasone SCHEMBL5037570 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL7755941 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL1462741 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL18762039 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL13046625 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL8809468 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL3183 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL5486743 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL5037573 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA | |
| Beclomethasone SCHEMBL5486747 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4NR3C1NFKB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902789-B1 | ANDROSTENE DERIVATIVES | SOFT DRUGS INC (US) | 2002-01-23 | — | — | EP | disclosed |
| US-4377575-A | Corticoid-17-(alkyl carbonates) and process for their manufacture | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-03-22 | — | — | US | disclosed |
| EP-0004975-B1 | 17-ALKYLCARBONATES OF CORTICOIDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINES AGAINST DERMATOSES | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-02-17 | — | — | EP | disclosed |
| US-4242334-A | ANTIINFLAMMATORY AGENTS; SKIN DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-12-30 | — | — | US | disclosed |
| EP-0004975-A2 | 17-Alkylcarbonates of corticoids, process for their preparation and their use as medicines against dermatoses | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-10-31 | — | — | EP | disclosed |