SCHEMBL7614950

SCHEMBL7614950

CCCCCCCCc1ccc(CCC(N)(CO)CCC)cc1

nearest known ligand 0.88

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 10/20 0.88
S1PR3 Q99500 9/20 0.88
S1PR4 O95977 7/20 0.88
TNNC1 P63316 6/20 0.88
S1PR5 Q9H228 5/20 0.88
SGPL1 O95470 1/20 0.88
GPR183 P32249 1/20 0.88
CERS2 Q96G23 1/20 0.88
SPHK2 Q9NRA0 3/20 0.74
SPHK1 Q9NYA1 1/20 0.74
S1PR2 O95136 5/20 0.72
ENPP2 Q13822 1/20 0.71
KDM4E B2RXH2 1/20 0.51
ALDH1A1 P00352 1/20 0.51
LMNA P02545 1/20 0.51
ESR1 P03372 1/20 0.51
SHBG P04278 1/20 0.51
TP53 P04637 1/20 0.51
CYP3A4 P08684 1/20 0.51
ADRA2A P08913 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7713904 0.98 S1PR1 (0.88) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL1372656 0.93 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
Fingolimod SCHEMBL7445 0.93 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3394554 0.93 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3393539 0.93 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3394797 0.93 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3390328 0.93 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL18904548 0.93 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3392313 0.93 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3389578 0.93 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778263-B1 BENZENE COMPOUND AND MEDICINAL USE THEREOF WELFIDE CORP (JP) 2002-01-09 EP claimed
EP-0778263-A1 BENZENE COMPOUND AND MEDICINAL USE THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1997-06-11 EP claimed
US-6372800-B1 IMMUNOSUPPRESSIVE EFFECT AND IS USEFUL AS AN INHIBITOR FOR THE REJECTION REACTION OCCURRING IN ORGAN OR BONE MARROW TRANSPLANTATION, AND AS A PREVENTIVE OR REMEDY FOR ARTICULAR RHEUMATISM, ATOPIC ECZEMA (DERMATITIS), BEHCET'S DISEASE, MITSUBISHI PHARMA CORPORATION (JP) 2002-04-16 US disclosed
EP-0778263-B1 BENZENE COMPOUND AND MEDICINAL USE THEREOF WELFIDE CORP (JP) 2002-01-09 EP disclosed
US-6187821-B1 SUCH AS 2-AMINO-2-(3-(4-HEPTYLPHENYL)PROPYL)BUTANE-1,4-DIOL; IMMUNOSUPPRESSANT; ADMINISTERING TO TREAT OR PREVENT AUTOIMMUNE DISEASES AND ALLERGIES WELFIDE CORPORATION (JP) 2001-02-13 US disclosed
EP-0778263-A1 BENZENE COMPOUND AND MEDICINAL USE THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1997-06-11 EP disclosed